What i would do:
1)download and run ad-aware
http://www.lavasoft.nu/
2)Disable or Prompt Active Scripting and Java in your browser. Many of these things get into your computer this way. You may have to enable java for some things ,but for the most part you won't notice much of a difference with it turned off. Depending on your browser, there is also a function to add trusted sites. Pop-up stoppers are unnecessary. Turning off java in your browser kills all pop-ups.